Type 2 Deiodinase A/G (Thr92Ala) Polymorphism and Circulating Thyroid Hormone Level of Childbearing Age Women in Area Replete with Iodine Deficiency Disorders

BACKGROUND: Iodothyronine deiodinase (DIO) is an enzyme that regulates thyroid hormone activity. DIO consists of three types: 1 (D1), 2 (D2), and 3 (D3). D2 a gene plays important role in regulation the biochemistry several tissues. also production triiodothyronine controlling signals. This study measured observation about 15% normal population show polymorphism (Thr92Ala) potentially affects activity D2. AIM: aimed to determine polymorphisms their association with levels women childbearing age replete iodine deficiency disorder areas. METHODS: Total number subjects was 131. Analysis serum TSH, T3, fT3, T4, fT4 done using ELISA. Polymorphism Thr92Ala analyzed by PCR-RFLP method. RESULTS: The results showed frequencies genotypes were AA 16.79%, AG 41.22%, GG 41.99%, whereas allele frequency A 37.5% G 62.5% (p HWE = 0.171). In this study, we found no differences TSH level between group each allel. Mean on range. CONCLUSION: associated rather than fT3 but not statistically significant. Heterozygous alleles at have higher compared homozygous alleles.